John Smith: [while driving, pursued by hit men in three black BMW'S] I never told you, but I was married once before.
Jane Smith: [slams on the brakes]
John Smith: What's wrong with you?
Jane Smith: [slapping John's arms and legs] You're what's wrong with me John.
John Smith: It was just a drunken Vegas thing.
Jane Smith: Oh, that's better. That's *much* better.
[pause]
Jane Smith: What's her name and social security number?
John Smith: No, you're not gonna kill her.

Mr. & Mrs. Smith är en actionfylld film om det vanliga paret John och Jane Smith, spelade av Brad Pitt och Angelina Jolie, som upptäcker att de båda är yrkesmördare för rivaliserande organisationer efter fem års äktenskap. Filmen utforskar deras dubbelliv och den spännande dynamiken mellan dem.