Doctor Marcia Fieldstone: People who truly loved once are far more likely to love again. Sam, do you think there's someone out there you could love as much as your wife?
Sam Baldwin: Well, Dr. Marcia Fieldstone, that's hard to imagine.
Doctor Marcia Fieldstone: What are you going to do?
Sam Baldwin: Well, I'm gonna get out of bed every morning… breathe in and out all day long. Then, after a while I won't have to remind myself to get out of bed every morning and breathe in and out… and, then after a while, I won't have to think about how I had it great and perfect for a while.
Doctor Marcia Fieldstone: Tell me what was so special about your wife?
Sam Baldwin: Well, how long is your program? Well, it was a million tiny little things that, when you added them all up, they meant we were supposed to be together… and I knew it. I knew it the very first time I touched her. It was like coming home… only to no home I'd ever known… I was just taking her hand to help her out of a car and I knew. It was like… magic.

Sömnlös i Seattle är en romantisk komedifilm som kretsar kring en ensamstående pappa, spelad av Tom Hanks, och en journalist, spelad av Meg Ryan. Handlingen tar sin början när sonen, spelad av Ross Malinger, ringer in till en radiostation för att hitta en ny mamma till sin pappa. Annie, spelad av Meg Ryan, hör samtalet och blir djupt berörd, vilket leder till en oväntad kärlekshistoria över långa avstånd.